STRUCTURAL ELUCIDATION OF TRANSITION METAL COMPLEXES OF MODIFIED DIAMINE ALONGWITH BIOASSAY STUDIES

S. U. Rehman, S. Noreen, Miss. Rashida, M. Akram, K. Ali, I. Ahmad, M. Arshad, I. H. Bukhari

Abstract


A number of complexes of modified diamine (3,7-dimethyl-1,5-dithia-3,7-diazacyclooctane), were prepared with first row divalent transition metals, i.e., Cu(II) and Zn(II). The structures of these complexes were elucidated on the basis of various physical techniques such as mass spectrometry, NMR, IR, UV-Visible spectroscopies, magnetic and conductance measurements. Bioassay of these complexes has also been carried out. The physical measurements confirm distorted tetrahedral structure for these complexes.

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References


P. J. Hendra and D. B. Powel, J. Chem. Soc.,

(1960) 5105.

F.G. Mann and H. R. Watson, J. Chem. Soc.,

(1958) 2772.

W. K. Musker and M. S. Hussain, Inorg.

Chem. 5, No. 8 (1966) 1416.

W. K. Musker and M. S. Hussain, Inorg.

Chem. 8, No. 3 (1969) 528.

D. O. Nielson, M. L. Larson, D.L. Smith and

J.I. Legg, J. Am. Chem. Soc. 90, No. 18

(1968) 5030.

M. S. Hussain and Saeed-ur-Rehman, Z.

Naturforsch. 33b (1978) 67.

M. S. Hussain and Saeed-ur-Rehman, Inorg.

Chimica Acta 60 (1982) 233.

(a) C. Hoose, K. Eberhardt, W. Hartmann

and W. Wosniok, Pneumologie. 44, No. 1

(1990) 458. (b) V. N. Saliaev, N. S. Titov and

V.P. Ermolaev, Farmakol Toksikol. 43, No. 4

(1980) 327.

H. Vidrio, G. Fernandez, M. Medina, E.

Alvarez and F. Orallo, Vascul.Phamacol. 40,

No. 1 (2003) 13.

J. Delaney and J. A. Timbrell, Xenobiotica

, No. 12 (1995) 1399.

W. D. MacRae and H. F. Stich, Mutat. Res.

, No. 4 (1979) 35.

M. Strolin-Benedetti and K. F. Tipton, J.

Neural Transm.Suppl. 52 (1998) 149.

S.R. Saunders and W. Karo, Organic

Functional Groups, Academic Press New

York & London (1968) pp. 363-384.

B.S. Holla, M. Mahalinga, M. S. Karthikeyan,

B. Poojary and P.M. Akber Ali, European

Journal of Medicinal Chemistry 40, No. 11

(2005) 1173.

B.N. Figgis, J. Lewis and R.G. Wikins, (Eds),

Modern Coordination Chemistry, Interscience, New York (1960) p. 412.

R. Chang, Physical Chemistry for the

Biosciences, University Science Books,

(2005) p. 482.

R. R. Roe and Yuan-Ping Pang, J. Mol.

Model. 5 (1999) 134.

B. Trzaskowski, L. Adamowicz and P.A.

Deymier, J. Biol. Inorg. Chem. 13 (2008) 133.

T. Dudev and C. Lim, J. Am. Chem. Soc. 122

(2000) 11146.

E. Meggers, Current Opinion in Chemical

Biology 11, No. 3 (2007) 287.

Vrednye veshchestva v promyshlennosti.

Spravochnik (Noxious Substances in

Industry: A Handbook), Lazarev, N.V., Ed.,

Leningrad: Khimiya, 1, 2 (1965)

Atta-ur-Rahman, M.I. Choudhary and W.J.

Thomsen, Bioassay Techniques for Drug

Development. Amsterdam, The Netherlands:

Harwood Academic, 2001.


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